温病邪入营血分实质的实验研究

本实验用内毒素诱发家兔全身性施瓦茨曼反应制成温病营血分证模型,并对其实质进行研究.通过病理学、血液学、微循环学及生化学等方法检查,证明本模型有血管内凝血、血液低凝和纤溶增强、血粘度增高、微循环障碍及线粒体、溶酶体和微粒体等细胞器的损伤,并有过氧化脂质增多.据此认为温病营血分证的实质是:感染引起弥散性血管内凝血、微循环障碍,多种细胞器损伤和氧自由基的毒害.

Experimental Study on the Essence of Ylngfen and Xuefen Srndromes of Epidemic Febrile Disease

The model of Yingfen and Xuefen syndromes of epidemic febrile disease was made in rabbits by endotoxin to induce generalized Shwartzman reaction. The essence of these syndromes was explored. By pathological , hematological, biochemical and microcirculation examinations, it was found that this model had intravascular coagulation, hypocoagulabiliby, hyperfibri-nolysis and hyperviscosity of blood, microcirculation dysfunction ,injury of mitochondria, lysosome and microsome,and excess of lipid peroxide. All of these results disclosed that the Yingfen and Xuefen syndromes of epidemic febrile disease was due to DIC induced by infection and microcirculation dysfunction, injury of organelles and poison of oxygen free radicals.