| 复方积雪草合剂对IgA肾病大鼠肾组织炎症因子和ECM表达的影响 |
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| 引用本文： | 王军,程晓霞,朱晓玲,陈洪宇,王永钧. 复方积雪草合剂对IgA肾病大鼠肾组织炎症因子和ECM表达的影响[J]. 中国中西医结合肾病杂志, 2008, 9(11): 949-952 |
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| 作者姓名： | 王军 程晓霞 朱晓玲 陈洪宇 王永钧 |
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| 作者单位： | 1. 浙江中医药大学,杭州,310007;浙江中医药大学附属广兴医院,杭州,310007
2. 浙江中医药大学附属广兴医院,杭州,310007 |
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| 基金项目： | 浙江省杭州市科技发展计划 |
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| 摘 要： | 目的：探讨复方积雪草合剂对实验性IgA肾病（IgAN）模型大鼠肾脏组织细胞外基质（ECM）和炎症因子表达的干预作用。方法：采用改良口服牛血清白蛋白（BSA）和尾静脉注射葡萄球菌肠毒素B（SEB）的免疫复合法建立大鼠实验性IgAN模型,40只大鼠随机分为正常组、模型组及复方积雪草合剂治疗组（设高、中、低3个剂量）。药物干预12周,分别观察实验大鼠尿蛋白、肾功能、血尿及肾病理的变化,并用免疫组化及半定量法检测肾组织中FN、IL-6、TGF-β1的含量。结果：复方积雪草治疗组能显著减少实验大鼠尿红细胞和尿蛋白（P〈0.05）,同时对实验大鼠肾组织TGF-β1、FN的表达均有明显抑制作用（P〈0.05）,但对IL-6的表达未见显著作用,且无明显剂量依从性。结论：复方积雪草合剂对IgAN模型鼠具有显著的治疗作用,能有效减少蛋白尿和红细胞,减轻肾组织的免疫损伤。其作用机制可能与其抑制或降低炎症因子的分泌有关,并最终延缓IgA肾病的发展。
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| 关 键 词： | 复方积雪草 IgA肾病 炎症因子 细胞外基质 |
The Effects of Centella Asiatica Compound on Renal Expression of Cytokines and ECM in Rats with IgAN |
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| WANG Jun,CHEN Xiaoxia,ZHU Xiaoling,et al The Guangxin Affilicated Hospital of Zhejiang University of TCM,Hangzhou. The Effects of Centella Asiatica Compound on Renal Expression of Cytokines and ECM in Rats with IgAN[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2008, 9(11): 949-952 |
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| Authors: | WANG Jun CHEN Xiaoxia ZHU Xiaoling et al The Guangxin Affilicated Hospital of Zhejiang University of TCM Hangzhou |
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| Affiliation: | WANG Jun,CHEN Xiaoxia,ZHU Xiaoling,et al The Guangxin Affilicated Hospital of Zhejiang University of TCM,Hangzhou (310007) |
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| Abstract: | Objective:To investgate the effects of centella asiatica compound on renal expression of cytokines and ECM in rats with IgAN.Methods:Rats model of IgAN were induced with an improved immune method,oral adminstration of BSA and injection of SEB via tail vein.Fourty rats were randomly divided into normal,IgAN model and centella asiatica treatment groups,and then divided further into three sub-groups:high dose,medium dose and low dose.At the 12th week,kidney pathology,serum creatinine (Scr),blood urea nitrogen ... |
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| Keywords: | Centella asiatica compound IgAN Cytokine ECM |
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