Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience |
| |
| Authors: | Yuji Nishiyama Ukihide Tateishi Kazuya Shizukuishi Ayako Shishikura Etsuko Yamazaki Hiroto Shibata Tomohiro Yoneyama Yoshiaki Ishigatsubo Tomio Inoue |
| |
| Institution: | 1. Departments of Radiology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan
2. Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
|
| |
| Abstract: | Purpose The aim of this study was to report our early experience with 18F-fluoride PET/CT for detecting lesions and evaluate the usefulness of this modality in the assessment of multiple myeloma (MM). Materials and methods 18F-fluoride PET/CT and 99mTc-MDP bone scintigraphy (BS) studies from 7 myeloma patients (4 male and 3 female, mean age 55 years) diagnosed according to standard criteria were reviewed retrospectively. Two reviewers visually and quantitatively analyzed the images and recorded their findings after reaching a consensus. Diagnostic certainty regarding the presence or absence of myeloma lesions was evaluated according to the reference standard consisting of whole-body magnetic resonance imaging and whole-body X-ray. Results A total of 93 affected areas were definite according to the reference standard. Of these, 83 affected areas (89 %) were identified on 18F-fluoride PET/CT, whereas 54 affected areas (58 %) were found on BS. Mean SUVmax in the affected areas was 9.8 ± 3.2 (standard deviation) ranging from 5.0 to 21.2. A total of s17 lesions with bone fracture were also detected by 18F-fluoride PET/CT and 2 lesions (12 %) were negative on BS. Conclusion Our result showed that 18F-fluoride PET was a possible modality to detect areas of lesions in patients with MM. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
