母血、脐血INS、GLUC、COR RIA及其意义

目的：测定胎龄儿（AGA）母血、脐血胰岛素（INS）、胰高血糖素（GLUC）、皮质醇（COR）水平，探讨AGA体重与孕妇体重指数（BMI）及母血脐血INS、GLUC、COR相关性及意义。方法：随机选取无明显产科并发症的母亲及新生儿，共26对，新生儿分为体重偏低组（A组）及体重偏高组（B组），采用放射免疫分析测定INS、GLUC、COR含量。结果：新生儿体重与孕妇BMI有明显关系，B组孕妇BMI显著高于A组（P〈0．05）；新生儿GLUC与COR水平与孕妇比较也具重要的统计学意义（P〈0．05，P〈0．01）；B组新生儿COR含量远高于A组水平（P〈0．01），而GLUC则相反（P〈0．05）。结论：胎儿发育与孕妇BMI及母血、脐血INS、GLUC及COR水平有关，提示母亲营养状况与上述三种代谢激素的分泌水平直接影响胎儿发育。

Significance of Determination of Insulin, Glucagon and Cortisol Levels in Maternal and Umbilical Cord Blood

Objective To determine the insulin(INS), glucagon(GLUC) and cortisol(COR) levels in maternal and umbilical cord blood for appropriate gestational age(AGA) neonates and to explore the correlation among the body weight of AGA neonates and body mass index(BMI) of pregnant woman,serum INS,GLUC,COR levels of maternal as well as umbilical cord blood.Methods Neonates fell into lower-than-normal body weight group(group A n=9) and higher-than-normal body weight group(gorup B n=17);serum INS,GLUC and COR levels were measured with radioimmunoassay in 26 pairs of mothers and neonates with uneventful delivery.Results The body weight of neonate was positively correlated with the BMI of pregnant women,the BMI of pregnant women in group B were significantly higher than those in group A(P<0.05).The maternal serum GLUC and COR levels were significantly higher than those in cord blood(P<0.05,P<0.01).Cord blood COR contents in group B were significantly higher than those in group A(P<0.01),the reverse was true for GLUC(P<0.05).Conclusion Fetal growth is closely related to the BMI of pregnant women and serum INS,GLUC and COR levels,indicating that maternal nutritional condition would directly affect the birth weight of the neonates.