| 膀胱尿路上皮癌Fas相关死亡结构域蛋白表达及意义 |
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| 引用本文： | 宋保连,罗波,刘国力.膀胱尿路上皮癌Fas相关死亡结构域蛋白表达及意义[J].青岛大学医学院学报,2008,44(5). |
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| 作者姓名： | 宋保连 罗波 刘国力 |
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| 作者单位： | 青岛大学医学院松山医院泌尿外科,山东,青岛,266021 |
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| 摘 要： | 目的 研究Fas相关死亡结构域 (FADD) 蛋白在膀胱尿路上皮癌(BUC)组织的表达,并探讨其与肿瘤生物学行为之间的关系.方法 采用免疫组化SP法检测68例BUC及13例正常膀胱黏膜组织FADD蛋白表达.原位杂交法检测其中34例BUC组织FADD mRNA 表达水平.结果 正常膀胱黏膜FADD蛋白呈阳性表达.FADD的阳性率在不同组织学分级、不同临床分期的BUC组织中差异均有极显著性(χ2=15.38、11.34,P<0.01);复发组与未复发组FADD的阳性率分别为36.84%和53.33%,差异无显著意义(χ2=1.85,P>0.05).BUC组织中FADD mRNA阳性率为44.12%, FADD蛋白阳性率为47.06%,两者差异无统计学意义(χ2=0.06,P>0.05).结论 FADD表达异常在BUC的发展中可能起着重要作用, FADD阳性表达与BUC病理分级、浸润关系密切,但与BUC复发无关.
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| 关 键 词： | Fas相关死亡结构域蛋白 膀胱肿瘤 免疫组织化学 原位杂交 |
EXPRESSION OF FADD IN UROTHELIAL CARCINOMA OF THE BLADDER |
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| SONG BAO-LIAN,LUO BO,LIU GUO-LI.EXPRESSION OF FADD IN UROTHELIAL CARCINOMA OF THE BLADDER[J].Acta Academiae Medicinae Qingdao Universitatis,2008,44(5). |
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| Authors: | SONG BAO-LIAN LUO BO LIU GUO-LI |
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| Institution: | SONG BAO-LIAN,LUO BO,LIU GUO-LI(Department of Urology,Songshan Hospital,Qingdao University Medical College,Qingdao 266021,China) |
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| Abstract: | Objective To investigate the Fas-associated death domain(FADD) protein and its biological behavior in bladder urothelial carcinoma(BUC). Methods The expressions of FADD in 68 BUC and 13 normal bladder tissue were detected by streptavidin-peroxidase immunohistochemical technique.Of which,34 BUC were studied by in-situ hybridization for FADD mRNA. Results The various exprssions of FADD were as follows: it positively expressed in normal bladder mucosa;the differences of positive expression were significant amo... |
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| Keywords: | Fas-associated death domain protein Bladder neoplasmas Immunohistochemistry In situ hybridization |
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