| 山莨菪碱对豚鼠实验性鼻超敏反应的影响 |
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| 引用本文： | 朱志华,董震,杨占泉.山莨菪碱对豚鼠实验性鼻超敏反应的影响[J].临床耳鼻咽喉头颈外科杂志,2001,15(5):218-220. |
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| 作者姓名： | 朱志华 董震 杨占泉 |
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| 作者单位： | 吉林大学第三临床医学院耳鼻咽喉-头颈外科 |
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| 摘 要： | 目的 :观察山莨菪碱对豚鼠实验性鼻超敏反应的影响。方法 :将实验动物分为正常对照组 ,二异氰酸甲苯脂 (TDI)致敏组 ,利血平组和山茛菪碱组 ,以其鼻部症状记分及鼻粘膜细胞学的变化作为观察项目。结果 :利血平组鼻部症状较 TDI致敏组明显加重 ,鼻粘膜嗜酸性粒细胞明显增高 ,其差异有极显著性意义 (均 P <0 .0 1)。山莨菪碱组鼻部症状明显减轻 ,嗜酸性粒细胞数明显减少 ,与利血平组比较 ,差异有显著性意义 (均 P <0 .0 1)。结论 :以副交感神经兴奋为主的鼻超敏反应性疾病 ,经鼻给予山莨菪碱有一定治疗作用。
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| 关 键 词： | 鼻超敏反应 山莨菪碱 副交感神经 |
| 文章编号： | 1001-1781(2001)05-0218-03 |
| 修稿时间： | 2000年8月24日 |
Influence of anisodamin on guinea pig experimental nasal hypersensitivity |
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| Zhu Zhihua,DONG Zhen,YANG Zhanquan.Influence of anisodamin on guinea pig experimental nasal hypersensitivity[J].Journal of Clinical Otorhinolaryngology,2001,15(5):218-220. |
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| Authors: | Zhu Zhihua DONG Zhen YANG Zhanquan |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery, Chinese Japan United Hospital of Jilin University, Changchun 130031. |
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| Abstract: | OBJECTIVE: To observe the influence of anisodamine on guinea pig experimental nasal hypersensitivity. METHOD: Experimental animals were divided into normal control group, TDI group, reserpine group and anisodamine group. The scores of symptom of nose and the cytologic changes of nasal mucosa were parameters of observing. RESULT: The nasal symptom of reserpine group was significantly stronger than the TDI group, and the eosinophilia evidently increased (both P < 0.01). The nasal symptom of the anisodamine group reduced and the eosinophilia decreased. It is significantly difference between the TDI group and the reserpine group (both P < 0.01). CONCLUSION: Anisodamine may play a role in therapy of the experimental nasal hypersensitivity with hyperfunction of parasympathetic nerve. |
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| Keywords: | Nasal hypersensitivity Anisodamine Parasympathetic |
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