动态超声弹性成像技术评估帕金森病肌强直程度的临床研究

目的 探讨动态超声弹性成像技术评估帕金森病骨骼肌生物力学特征的价值.方法 选取2019年1月至9月在首都医科大学附属北京天坛医院入院、明确诊断为帕金森病的患者28例作为帕金森病组,选取同期健康志愿者作为健康对照组,共10名.应用超声弹性成像技术完成2组受试者腓肠肌动态弹性检查,记录被动背屈踝关节过程中,关节角度对应的腓...

Quantification of passive muscle stiffness in Parkinson's disease by dynamic shear wave elastography

ObjectiveTo investigate the clinical value of dynamic shear wave elastography in the evaluation of muscular rigidity in Parkinson's disease. MethodsFrom January to September 2019, 28 patients confirmed with Parkinson's disease and 10 healthy controls at Beijing Tiantan Hospital, Capital Medical University were recruited. Dynamic shear wave elastography was used to record the elastic modulus of the medial gastrocnemius during the ankle joint passive dorsiflexion, the curves of elastic modulus-ankle joint angles were described, and the differences of curve parameters, muscle elastic modulus in relaxation (E₀), and slack angle (beyond which the muscle begins to develop passive tension) between the two groups were compared by t-test. ResultsThe mean E₀ in the Parkinson's disease group was significantly lower than that in the healthy control group (10.30±2.75) kPa vs (11.64±1.26) kPa; t=-2.704, P＝0.009). The slack angle in the Parkinson's disease group was significantly smaller than that of the healthy control group (-27.49±5.23)° vs (-21.77±4.58)°; t=-4.168, P＜0.001). There was no significant difference in gastrocnemius muscle thickness or muscle length between the two groups (P＞0.05). ConclusionDynamic shear wave elastography can be used to detect the biomechanical characteristics of Parkinson's disease, such as the state of muscle rigidity.