2005—2016年中国女性卵巢癌发病及死亡趋势研究

背景卵巢癌对女性健康的危害已得到全世界的广泛关注，但目前缺乏针对我国卵巢癌发病及死亡趋势分析的研究。目的通过收集《中国肿瘤登记年报》中2005—2016年卵巢癌发病与死亡数据，描述和分析该时期我国女性卵巢癌发病与死亡变化趋势，为我国卵巢癌的科学防控提供参考依据。方法整理2005—2016年卵巢癌发病与死亡数据，计算每年的标化发病率、标化死亡率、年龄别发病率和年龄别死亡率。运用Joinpoint软件计算年度变化百分比（APC）和平均年度变化百分比（AAPC），分析我国卵巢癌发病与死亡随时间（年度）的变化趋势。结果2005—2016年我国卵巢癌发病率整体呈快速上升趋势（AAPC=7.25%，P<0.05），历年城市的卵巢癌标化发病率均高于农村，35~岁年龄组以后发病率随年龄增长呈上升趋势，发病高峰主要集中出现在55~岁年龄组。2005—2016年我国卵巢癌死亡率整体呈快速上升趋势（AAPC=6.06%，P<0.05），历年城市卵巢癌标化死亡率均高于农村，35~岁年龄组以后死亡率随年龄的增长快速上升，75~岁年龄组以后死亡率逐渐下降。结论2005—2016年我国卵巢癌发病率和死亡率呈快速上升趋势，但在年龄和城乡之间表现出一定差异，应采取针对性措施，积极制订卵巢癌防治策略，降低卵巢癌的危害。

Ovarian Cancer in China:Trends in Incidence and Mortality,2005-2016

Background The health impairment caused by ovarian cancer in female population has become a global focus.However,there is a lack of research on ovarian cancer incidence and mortality trends in Chinese female population.Objective To describe the trends of ovarian cancer incidence and mortality in China from 2005 to 2016 by analyzing the incidence and death data of ovarian cancer collected from Chinese Cancer Registry Annual Report,providing a basis for the scientific prevention and control of ovarian cancer in China.Methods The incidence and mortality of ovarian cancer in China during 2005 to 2016 were collected and input into Excel spreadsheets,then the annual age-standardized incidence rate,age-standardized mortality rate,age-specific incidence rate and age-specific mortality rate were computed.Joinpoint Regression Program was used to estimate the annual percentage change(APC),and average annual percentage change(AAPC)to analyze the temporal trends of annual ovarian cancer incidence and mortality rates.Results The incidence rate of ovarian cancer showed a trend of rapid increase over the period of 2005 to 2016(AAPC=7.25%,P<0.05).The annual age-standardized ovarian cancer incidence rate in urban areas was higher than that in rural areas in each year.The ovarian cancer incidence rate increased obviously with age in women over the age of 35,and peaked in those aged 55 years old.From 2005 to 2016,the overall ovarian cancer mortality rate showed a rapid upward trend(AAPC=6.06%,P<0.05).The age-standardized ovarian cancer mortality rate in urban areas was higher than that in rural areas.The mortality rate increased rapidly with age in women over 35 years of age,but decreased gradually in those aged over 75 years.Conclusion Both ovarian cancer incidence and mortality rates during 2005 to 2016 in China increased rapidly,but with age-specific and urban-rural differences.Therefore,targeted interventions should be taken,and strategies for ovarian cancer prevention and treatment should be developed to reduce the risk of ovarian cancer.