基于短链脂肪酸防治代谢性疾病的研究进展

短链脂肪酸（SCFAs）是一类含有1~6个碳原子的饱和脂肪酸，主要由肠道内特定菌群通过发酵膳食纤维产生，对维持肠道内环境稳态发挥重要作用。近年来研究表明SCFAs可调节糖脂代谢、调节能量平衡、维持肠道屏障、减轻炎性反应，并通过上述多途径参与2型糖尿病、肥胖、脂代谢紊乱、非酒精性脂肪性肝病等代谢性疾病的发生与发展。本文总结了SCFAs调控代谢的机制及其防治代谢性疾病的研究进展，旨在为代谢性疾病的防治提供更多参考资料。

Research Progress of the Prevention and Treatment of Metabolic Diseases Based on Short Chain Fatty Acids

Short chain fatty acids(SCFAs)are a class of saturated fatty acids containing 1-6 carbon atoms,which are mainly produced by specific flora in the intestine through the fermentation of dietary fiber,and play an important role in maintaining the homeostasis of the intestinal environment.Recent studies have shown that SCFAs can regulate glucose and lipid metabolism,regulate energy balance,maintain the intestinal barrier and reduce inflammatory responses,eventually participating in the occurrence and development of metabolic diseases such as type 2 diabetes mellitus,obesity,lipid metabolic disorders and nonalcoholic fat liver disease through the above multiple pathways.This article summarizes the mechanism of SCFAs regulating metabolism and the research progress in the prevention and treatment of metabolic diseases,in order to provide more reference materials for the prevention and treatment of metabolic diseases.