多糖抗2型糖尿病作用机制研究进展及分析

多糖是由10个以上单糖分子通过糖苷键连接形成的大分子化合物.多糖来源广泛、安全低毒,且具有抗肿瘤、抗病毒、免疫调节、降血糖、降血脂等多种生物活性,受到研究学者的广泛关注.2型糖尿病(type 2 diabetes mellitus,T2DM)是一种以高血糖、胰岛素抵抗、低度炎症为特征的慢性代谢紊乱疾病.近年来,多糖对T...

Research progress and analysis on mechanism of polysaccharides against type 2 diabetes mellitus

Polysaccharides are macromolecular compounds formed by more than 10 monosaccharide molecules linked by glycosidic bonds.Polysaccharides have a wide range of sources,high safety and low toxicity,with a variety of biological activities,such as anti-tumor,anti-virus,immune regulation,lowering blood glucose,and lowering blood lipids.Type 2 diabetes mellitus(T2 DM)is a chronic metabolic disorder characterized by hyperglycemia,insulin resistance and low inflammation.In recent years,the treatment of T2 DM with polysaccharide has become a research hotspot.Polysaccharides can not only make up for the side effects such as hypoglycemia,weight gain,gastrointestinal injury caused by long-term treatment of acarbose,biguanidine and sulfonylurea,but also play an effective role in reducing glucose by regulating glucose metabolism,oxidative stress,inflammatory response,intestinal flora,etc.In this paper,the research progress of polysaccharides in the treatment of T2 DM was reviewed.In addition,the hot spots such as the hypoglycemic activity of polysaccharides with structural modifications were summarized,providing theoretical guidance for the development of active polysaccharide hypoglycemic medicines and the further study of action mechanism.