G蛋白偶联受体在血压调节中的新作用

高血压是指以全身动脉血压升高为特征的临床综合征,可能伴有心、脑、肾等器官的功能性或器质性损害.高血压致病和发展受遗传、环境、表观遗传、肠道微生物等因素影响,它们是促进血压水平和血管阻力变化的多种因素综合作用的结果.G蛋白偶联受体(GPCRs)是跨细胞膜传递信号转导并介导人体生理所需的大量细胞反应的跨膜受体的最大和最多样...

New effect of G-protein coupled receptors on blood pressure regulation

Hypertension is a clinical syndrome characterized by elevated systemic arterial blood pressure,which may be accompanied by functional or organic damage of heart,brain,kidney and other organs.The pathogenesis and development of hypertension are affected by genetic,environmental,epigenetic,intestinal microbiota and other factors.They are the result of multiple factors that promote the change of blood pressure level and vascular resistance.G protein coupled receptors(GPCRs)are the largest and most diverse superfamily of transmembrane receptors that transmit signals across cell membranes and mediate a large number of cellular responses required by human physiology.A variety of GPCRs are involved in the control of blood pressure and the maintenance of normal function of cardiovascular system.Hypertension contributes to the damages of heart,brain,kidney,intestine and other organs.Many GPCRs are expressed in various organs to regulate blood pressure.Although many GPCRs have been used as therapeutic targets for hypertension,their efficacy has not been fully studied.The purpose of this paper is to elucidate the role of GPCRs in blood pressure regulation and its distribution in target organs.The relationship between GPCRs related to intestinal microorganisms and blood pressure is emphasized.It is proposed that traditional Chinese medicine may be a new way to treat hypertension by regulating the related GPCRs via intestinal microbial metabolites.