基于细胞信号通路探讨小檗碱治疗溃疡性结肠炎研究进展

小檗碱是黄连属植物的主要提取物,经现代研究已确证其有抗炎、抗氧化、抗菌及免疫调节等药理作用。溃疡性结肠炎(UC)是一种病因不明的慢性,特发性炎性肠病,其发病原因涉及遗传,肠道微生态和黏膜免疫系统失调等因素。该文通过查阅,梳理近年来小檗碱对溃疡性结肠炎的相关通路及其作用机制,为开展小檗碱治疗UC的药物开发及机制探讨提供方法与思路。结果显示,小檗碱通过调节JAK-STAT,NF-κB,PI3K-AKT,MAPK,Nrf2,ERS和MLCK-MLC等多条信号通路,发挥保护肠黏膜屏障、恢复机体正常免疫应答、抗氧化应激等作用,进而达到治疗UC的目的。

Research progress of effect of berberine in treatment of ulcerative colitis based on cell signaling pathway

Berberine is the main extract of Coptis chinensis,and its anti-inflammatory,antioxidant,antibacterial and immunomodulatory effects have been confirmed by modern studies.Ulcerative colitis(UC)is a chronic,idiopathic inflammatory bowel disease with unknown etiology.Its causes involve genetics,intestinal microecology and mucosal immune system disorders.In this paper,literatures on relevant pathways and mechanism of berberine on ulcerative colitis in recent years were consulted and summarized to provide methods and ideas for developing berberine in the treatment of UC and exploring the mechanisms.The results showed that berberine protects the intestinal mucosal barrier,restores the body's normal immune response,and improves oxidative stress by regulating multiple signaling pathways,such as JAK-STAT,NK-κB,PI3K-AKT,MAPK,Nrf2,ERS,and MLCK-MLC,so as to treat UC.