中年女性亚油酸摄入与类风湿性关节炎的相关性

目的 研究中年女性每日膳食亚油酸摄入量与类风湿性关节炎(RA)的关系.方法 本研究数据来自美国妇女健康研究(SWAN)1996～1997年基线数据.纳入标准:近3个月内没有使用性激素;近3个月内月经出血;目前没有怀孕或哺乳;子宫完整,卵巢至少1个;42～52岁女性.排除饮食信息和疾病信息不全的研究对象.类风湿性关节炎的...

Study on relationship between linoleic acid intake and rheumatoid arthritis

Objective To study the relationship between daily linoleic acid intake and rheumatoid arthritis(RA).Methods Data were obtained from the Study of Women's Health Across the Nation(SWAN)1996-1997 baseline data.Women who met the eligibility criteria were 42~52 years old,had an intact uterus and at least one intact ovary,had not used reproductive hormones in the previous three months and had at least one menstrual period.Women were excluded due to missing information regarding diet and RA.Women suffered from RA and were classified as arthritis group,the rest were classified as control group.Dietary intake was estimated through the 1995 Dietary Frequency Questionnaire.Mann-Whitney U test was used to compare the difference of mean values between groups.Chi-square test was performed to compare differences of rate between groups.Logistic regression analysis were used to exam the relationship between dietary linoleic acid and RA.Restrictive cubic spline analysis was performed to exam non-linear relationships.Results Among the 3121 subjects,627(20.09%)suffered from RA.Compared with the control group,the arthritis group had higher linoleic acid intake(Z=-2.403,P=0.016).In the unadjusted covariate model,linoleic acid intake was positively correlated with RA.This relationship still existed in Model 1,which adjusted socio-economic factors.After fully adjusting the socioeconomic and clinical factors,linoleic acid intake was positively correlated with RA riskodds ratio(OR)=1.597,95%confidence interval(CI)(1.211,2.107)]for the highest quartile spacing compared with the lowest quartile spacing.Restricted cubic spline regression showed that linoleic acid intake and the risk of rheumatoid arthritis presented as polyline-shape.Multivariate analysis showed that age,triglyceride,LDL-C and linoleic acid intake were positively correlated with prevalence of RAOR=1.051,95%CI(1.014,1.089),OR=1.004,95%CI(1.002,1.006),OR=1.013,95%CI(1.005,1.022),OR=1.009,95%CI(1.002,1.017),all P<0.05].Education level,average exercise index,menstrual state and total cholesterol were negatively correlated with prevalence of RAOR=0.870,95%CI(0.803,0.944),OR=0.878,95%CI(0.785,0.981),OR=0.723,95%CI(0.596,0.877),OR=0.986,95%CI(0.978,0.994),all P<0.05].Conclusion The intake of linoleic acid is positively correlated with the RA.Linoleic acid serves as a point of breakthrough in the prevention and treatment of RA.