静脉用药调配中心75%乙醇不同喷雾量消毒瓶塞效果观察

目的 探讨75%乙醇不同喷雾量消毒瓶塞的消毒效果及待干时间，以选择适宜喷雾量。方法 选择同批号西林瓶200瓶，随机分成对照组、实验A组、实验B组和实验C组，每组50瓶。对照组采用75%乙醇擦拭消毒，实验组采用75%乙醇喷雾式消毒，每个西林瓶消毒1次，实验A组、B组、C组单次喷雾量分别为0.10 mL、0.13 mL和0.16 mL。分别记录每瓶西林瓶消毒后的待干时间并取样进行细菌培养。结果 四组均未检出细菌，合格率为100%。对照组与实验A、B、C组的消毒待干时间分别为(77.82±13.02)s、(61.76±8.26)s、(69.60±8.84)s和(78.62±8.46)s，组间比较除对照组与实验C组差异无统计学意义（P>0.05）外，其余两两比较差异有统计学意义（均P<0.01）。结论 静脉用药调配中心选择75%乙醇单次喷雾量0.13 mL对瓶塞进行消毒，可保证消毒效果且减少消毒待干时间，提高工作效率。

Effect observation of dosing port disinfection with 75% ethanol at different spray volume in pharmacy intravenous admixture service

Objective To explore the disinfection effect and drying time of dosing port disinfection with 75% ethanol at different spray volume, so as to choose suitable spray volume. Methods Totally 200 penicillin bottles of the same batch were selected and randomized into a control group, an experimental group A, an experimental group B and an experimental group C, with 50 bottles in each group. The control group was disinfected by wiping with 75% ethanol, and the experimental group was disinfected by spraying with 75% ethanol. Each penicillin bottle was disinfected once, the single spray volume of the experiment group A, B and C was 0.10 mL, 0.13 mL and 0.16 mL respectively. The drying time of each penicillin bottle after disinfection was recorded, and samples were collected for culture of bacteria.Results No bacteria were detected in the four groups, the qualified rate was 100%. The drying time of the control group and the experimental group A, B, and C was (77.82±13.02) s, (61.76±8.26) s, (69.60±8.84) s and (78.62±8.46) s respectively. There were significant differences between each two groups (P<0.01 for all) except for the control group and the experimental group C (P>0.05).Conclusion Selection of a single spray of 75% ethanol at around 0.13 mL for dosing port disinfection in pharmacy intravenous admixture service, can guarantee disinfection effect and reduce drying time, then improve working efficiency.