| Effect of Moniliformin on Myocardial Contractility in Rats |
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| 引用本文： | FANLILI LIJUAN 等. Effect of Moniliformin on Myocardial Contractility in Rats[J]. Biomedical and environmental sciences : BES, 1991, 4(3): 290-294 |
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| 作者姓名： | FANLILI LIJUAN 等 |
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| 作者单位： | [1]InstituteofMateriaMedica,ChineseAcademyofMedicalSciences，1XianNongTanStreet,Beijing100050 [2]Instituteo,ChineseAcademyofMedicalSciences，1XianNongTanStreet,Beijing100050 |
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| 摘 要： | The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10-7 mol/liter in isolated heart decreased myocardial contractile force by 52±17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD_(50) markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased 4±LV dP/dt max by 52±6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease.
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| 关 键 词： | 串珠镰刀菌素 大鼠 心肌收缩力 作用机理 |
Effect of moniliformin on myocardial contractility in rats. |
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| L L Fan,J Li,L H Sun. Effect of moniliformin on myocardial contractility in rats.[J]. Biomedical and environmental sciences : BES, 1991, 4(3): 290-294 |
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| Authors: | L L Fan J Li L H Sun |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing. |
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| Abstract: | The present study was carried out on rat heart to in situ determine the myocardial toxicity of moniliformin, a synthesized compound, originally isolated from mouldy corn and soil samples in the Keshan disease prevalent area in China. Perfusion of moniliformin 10(-7) mol/liter in isolated heart decreased myocardial contractile force by 52 +/- 17%. Intravenous injection of moniliformin at 1/6 and 1/4 LD50 markedly inhibited cardiac hemodynamic variables relative to myocardial contractile function. Particularly, it decreased +/- LV dP/dt max by 52 +/- 6%, and induced ventricular arrhythmia. These data indicate that moniliformin is toxic to mammalian heart and might be an important factor relative to Keshan disease. |
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