宫颈癌中环氧合酶2与血管内皮生长因子C的表达及相关研究

目的：探讨环氧合酶2（COX-2）和血管内皮生长因子C（VEGF—C）在宫颈癌中的表达及意义。方法：应用免疫组织化学S—P法检测42例宫颈癌、20例宫颈上皮内瘤样变（CINⅠ～Ⅲ）、10例正常宫颈组织中COX-2和VEGF—C的表达。结果：宫颈癌组COX-2和VEGF—C阳性表达率分别高于CIN组及正常宫颈组（P〈0．05）。不同年龄、预后COX-2表达无差异（P〉0．05），但不同病理类型和临床分期间表达差异有统计学意义（P〈0．05）。不同年龄、病理类型、预后VEGF-C表达无差异（P〉0．05），但不同临床分期间表达差异有统计学意义（P〈0．05）。COX-2和VEGF-C在宫颈癌组织中的表达呈正相关（r=0．41，P〈0．05）。结论：COX-2和VEGF—C在宫颈癌的发生发展中起重要作用。可能作为宫颈癌早期诊断和判断预后的重要指标。

Expression and Their Correlation of COX-2 and VEGF-C in Cervical Cancer

Objective： To analyze the expression and correlation of COX-2 and VEGF-C in cervical cancer. Methods： The expressions of COX-2 and VEGF-C were detected by immunohistochemistry staining in 42 specimens of cervical cancer, 20 specimens of CIN（CIN Ⅰ～Ⅲ）, and 10 specimens of normal cervical tissue. Results： The expressions of COX-2 and VEGF-C were higher in tissue of cervical cancer than those in CIN and normal cervical tissue （P〉0.05）. The expression of COX-2 had no significant differences with age and prognosis（P〉0.05）. There were significant differences with patho-category and clinical stages （P〈0.05）. Meanwhile, the expression of VEGF-C had no significant differences with age, patho-category and prognosis （P〉0.05）. The expression of VEGF-C had big differences among clinical stages （P〈0.05）. A significant positive correlation was found between COX-2 and VEGF-C （r=0.413, P〈0.05）. Conclusion： COX-2 and VEGF-C seems to play important roles in carcinogenesis and progress of cervical cancer, and could be significant markers for early diagnose and predicting prognosis.