Suspended moxibustion at Tianshu (ST25) inhibits prokineticin 1 and prokineticin receptor 1 expression in the spinal cord of rats with chronic visceral hypersensitivity |
| |
| Authors: | Chen Zhao Li Qi Luyi Wu Tao Yi Huangan Wu Xinxin Guo Cili Zhou Huirong Liu Xiaomei Wang |
| |
| Institution: | (Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China) ； |
| |
| Abstract: | Suspended moxibustion can decrease the expression of prokineticin 1 and its receptor in colonic tissue from rats modeling chronic visceral hyperalgesia. This study aimed to verify if rat spinal cord prokineticin 1 and its receptor contribute to the analgesic effect of suspended moxibustion in a rat model of irritable bowel syndrome where rats display chronic visceral hypersensitivity. Results showed that suspended moxibustion at Tianshu (ST25) point significantly decreased visceral sensitivity to colorectal distention in a chronic visceral hyperalgesia rat model; also protein and mRNA expression of prokineticin 1 and prokineticin receptor 1 in the spinal cord of rats was significantly decreased. Experimental findings indicate that prokineticin 1 and prokineticin receptor 1 are involved in the analgesia using suspended moxibustion in rats with chronic visceral hyperalgesia. |
| |
| Keywords: | suspended moxibustion chronic visceral hypersensitivity irritable bowel syndrome prokineticin 1 prokineticin receptor 1 spinal cord neural regeneration |
| 本文献已被 CNKI 等数据库收录！ |
