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Perlecan and synaptophysin changes in denervated skeletal muscle
Authors:Kai Ma  Zhifeng Huang  Jianfeng Ma  Longquan Shao  Huiming Wang  Yanliang Wang
Institution:(Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Medical College of Zhejiang University, Hangzhou 310006, Zhejiang Province, China) ;
Abstract:The present study observed sciatic nerve and gastrocnemius muscle changes in denervated rats using morphology methods,and assessed expression of perlecan,an extracellular matrix com-ponent,which is located at the skeletal muscle cell surface as acetylcholine esterase,as well as synaptophysin,a synaptic marker.Results showed degeneration and inflammation following transection of the sciatic nerve.In addition,the sciatic nerve-dominated skeletal muscle degen-erated with mild inflammation,indicating that skeletal muscle atrophy primarily contributed to denervation-induced nutritional disturbances.With prolonged injury time(1-4 weeks post-injury),perlecan expression gradually decreased and reached the lowest level at 4 weeks,but synap-tophysin expression remained unchanged after denervation.Results suggested that perlecan expression was more sensitive to denervation and reflected regional extracellular matrix changes following denervation.
Keywords:perlecan  synaptophysin  extracellular matrix  acetylcholine esterase  neuromuscular junction  de-nervated  skeletal muscle  sciatic nerve  neural regeneration
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