Perlecan and synaptophysin changes in denervated skeletal muscle |
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Authors: | Kai Ma Zhifeng Huang Jianfeng Ma Longquan Shao Huiming Wang Yanliang Wang |
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Institution: | (Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Medical College of Zhejiang University, Hangzhou 310006, Zhejiang Province, China) ; |
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Abstract: | The present study observed sciatic nerve and gastrocnemius muscle changes in denervated rats using morphology methods,and assessed expression of perlecan,an extracellular matrix com-ponent,which is located at the skeletal muscle cell surface as acetylcholine esterase,as well as synaptophysin,a synaptic marker.Results showed degeneration and inflammation following transection of the sciatic nerve.In addition,the sciatic nerve-dominated skeletal muscle degen-erated with mild inflammation,indicating that skeletal muscle atrophy primarily contributed to denervation-induced nutritional disturbances.With prolonged injury time(1-4 weeks post-injury),perlecan expression gradually decreased and reached the lowest level at 4 weeks,but synap-tophysin expression remained unchanged after denervation.Results suggested that perlecan expression was more sensitive to denervation and reflected regional extracellular matrix changes following denervation. |
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Keywords: | perlecan synaptophysin extracellular matrix acetylcholine esterase neuromuscular junction de-nervated skeletal muscle sciatic nerve neural regeneration |
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