Ketamine inhibits c-Jun protein expression in mouse hippocampus following cerebral ischemia/reperfusion injury |
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| Authors: | Feng Xiao Liangzhi Xiong Qingxiu Wang Long Zhou Qingshan Zhou |
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| Affiliation: | (Department of Anesthesiology, Affiliated Taihe Hospital of Yunyang Medical College, Shiyan 442000, Hubei Province, China) ； |
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| Abstract: | A model of cerebral ischemia and reperfusion was established in mice.Mice were treated with ketamine via intraperitoneal injection immediately following ischemia or ischemia/reperfusion.Ketamine did not remarkably change infarct volume in mice immediately following ischemia,but injection immediately following ischemia/reperfusion significantly decreased infarct volume.Ketamine injection immediately after ischemia or ischemia/reperfusion inhibited c-Jun protein expression in mouse hippocampus,but nuclear factor kappa B expression was unaltered.In addition,the Longa scale score for neural impairment was not reduced in mice following cerebral ischemia/reperfusion.These results indicate that ketamine can protect mice against cerebral ischemia and reperfusion injury by modulating c-Jun protein expression in mouse hippocampus. |
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| Keywords: | ketamine ischemia/reperfusion c-Jun nuclear factor kappa B infarct volume |
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