首页 | 本学科首页   官方微博 | 高级检索  
检索        

盐藻β-胡萝卜素预防实验性动脉粥样硬化形成的形态学观察
引用本文:王春波,蓝孝贞,白玲,张仁亮,张鲁平,周绪祥,张敏,王玉贞,刘建国,张京浦.盐藻β-胡萝卜素预防实验性动脉粥样硬化形成的形态学观察[J].中国海洋药物,1998,17(2):6-10.
作者姓名:王春波  蓝孝贞  白玲  张仁亮  张鲁平  周绪祥  张敏  王玉贞  刘建国  张京浦
作者单位:青岛大学医学院,青岛大学医学院,青岛大学医学院,青岛大学医学院,青岛大学医学院,青岛大学医学院,青岛大学医学院,青岛大学医学院,中国科学院海洋研究所,中国科学院海洋研究所 青岛 266021,青岛 266021,青岛 266021,青岛 266021,青岛 266021,青岛 266021,青岛 266021,青岛 266021,青岛 266071,青岛 266071
基金项目:国家科委“八五”攻关课题(85-07-08)
摘    要:以鹌鹑动脉粥样硬化(AS)为模型,对从盐泽杜氏藻中提取的以顺式结构为主的β-胡萝卜素(β-C)预防实验性AS进行病理形态学观察,发现Ⅱ组(高饲对照组)动脉病变重,泡沫细胞约10~20层,平滑肌细胞增生,斑块发生率为91.67%。β-C组动脉病变轻,泡沫细胞仅约2~4层,斑块发生率明显少于Ⅱ组(P<0.05),且存在剂量依赖关系。结果表明,β-C能有效地抑制AS斑块的形成和发展。

关 键 词:实验性动脉粥样硬化  斑块  泡沫细胞  预防  发生率  形态学观察  β-胡萝卜素  病变  盐藻  剂量

MORPHOLOGICAL EVALUATION OF BETA-CAROTENE IN THE PREVENTION OF EXPERIMENTAL ATHEROSCLEROSIS IN QUAILS
Wang Chunbo,Lan Xiaozhen,Bai Ling,et al..MORPHOLOGICAL EVALUATION OF BETA-CAROTENE IN THE PREVENTION OF EXPERIMENTAL ATHEROSCLEROSIS IN QUAILS[J].Chinese Journal of Marine Drugs,1998,17(2):6-10.
Authors:Wang Chunbo  Lan Xiaozhen  Bai Ling  
Abstract:Beta-carotene(B-C) was isolated from Dunaliella salina and mainly composed of cis-isomer beta-carotene. A total of 81 experimental atherosclerotic quails were surveyed with morphological methods- It was found that the lessions in hypercholesterol group were severe with the incidence of atherogenic plaque being 91. 67%,and were mild in B-C groups with the incidence 88- 90% ,75% ,66. 7% , respectively. Significant difference was observed a- mong the groups (P<0. 05). Histological examinations showed that there were 10--20 layers of foam cells in hypercholesterol group,and 2-4 layers in B-C groups,which suggested that the proliferation of smooth muscle cells of B-C groupswas much less than that of control group. The results indicated that B-C could significantly inhibit atherosclerosis.
Keywords:
本文献已被 CNKI 等数据库收录!
点击此处可从《中国海洋药物》浏览原始摘要信息
点击此处可从《中国海洋药物》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号