Linkage analysis of the nevoid basal cell carcinoma syndrome

Twelve pedigrees were informative for linkage between the gene locus for the nevoid basal cell carcinoma syndrome and the ABO, MNS, Rh, P, Kell, Lewis, Ddy, and Kidd blood group marker loci. Linkage with a recombination fraction less than θ= 0.1 was unlikely for any marker locus. The most favourable of the possible loose linkages, that between the syndrome locus and Rh locus, showed a 12% probability of linkage when the prior odds against two autosomel loci being on the same chromosome were taken into account. The other marker loci manifested probabilities averaging about 3%.