| 大叶柴胡的毒性成分 |
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| 引用本文： | 赵吉福,郭允珍,孟宪纾. 大叶柴胡的毒性成分[J]. 药学学报, 1987, 22(7): 507-511 |
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| 作者姓名： | 赵吉福 郭允珍 孟宪纾 |
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| 作者单位： | 沈阳药学院(赵吉福，郭允珍)，沈阳药学院(孟宪纾) |
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| 摘 要： | 从伞形科植物大叶柴胡Bupleurum logiradiatum Turcz.的根及根茎中分得四种新的多烯炔类化合物,分别命名为柴胡毒素(bupleurotoxin,Ⅰ)柴胡酮醇(bupleuonol,Ⅱ),乙酰柴胡毒素(acetyl-bupleufotoxin,Ⅲ)和柴胡炔醇(bupleurynol,Ⅳ)。根据理化性质和光谱数据确定柴胡炔醇(Ⅳ)为十七碳三烯-(2z,8 E,10 E)-二炔-(4,6)-醇-1;柴胡毒素(Ⅰ)为14-羟基柴胡炔醇;乙酰柴胡毒素(Ⅲ)为14-乙酰氧基柴胡炔醇;柴胡酮醇(Ⅱ)为14-羰基柴胡炔醇。柴胡毒素(Ⅰ)和乙酰柴胡毒素(Ⅲ)有毒性。
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| 关 键 词： | 大叶柴胡 毒性成分 柴胡毒素 乙酰柴胡毒素 柴胡酮醇、柴胡炔醇 |
| 收稿时间： | 1986-06-25 |
THE TOXIC PRINCIPLES OF BUPLEURUM LONGIRADIATUM |
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| ZHAO Ji-FU,GUO Yun-Zhen and MENG Xian-Shu. THE TOXIC PRINCIPLES OF BUPLEURUM LONGIRADIATUM[J]. Acta pharmaceutica Sinica, 1987, 22(7): 507-511 |
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| Authors: | ZHAO Ji-FU GUO Yun-Zhen MENG Xian-Shu |
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| Abstract: | Four new compounds of polyenynic type were isolated from the ether extract of Bupleurum longiradiatum Turcz. (Umbellifarae) and were named bupleurotoxin, bupleuronol, acetyl-bupleurotoxin and bupleurynol. Bupleurotoxin and acetyl-bupleurotoxin are the toxic principles of Bupleurum longiradiatum Turcz. The LD_(50) for bupleurotoxin in mice (i.p. injection) is 3.03 mg/kg and for acetylbupleurotoxin 3.13 mg/kg.Physical, chemical and spectroscopic evidence supports bupleurynol as heptadecatren-(2Z, 8E, 10E)-diyne-(4,6)-ol-1, bupleurotoxin as 14-hydroxyl-bupleurynol, acetyl-bupleurotoxin as 14-acetoxy-bupleurynol and bupleuronol as 14-carbonyl-bupleurynol. |
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| Keywords: | Bupleurum longiradiatum Turcz. Toxic principles Bupleurotoxin Acetyl-bupleurotoxin Bupleuronol Bupleurynol |
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