| 正常及紫外线照射小鼠抗原呈递细胞在接触性过敏反应中的特性 |
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| 引用本文： | 唐军民,MDACC,ML Kripke,K Dunner Jr,C Bucana. 正常及紫外线照射小鼠抗原呈递细胞在接触性过敏反应中的特性[J]. 北京大学学报(医学版), 1993, 0(5) |
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| 作者姓名： | 唐军民 MDACC ML Kripke K Dunner Jr C Bucana |
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| 作者单位： | 北京医科大学组织学胚胎学教研室(唐军民)，美国德州大学(MDACC，ML Kripke，K Dunner Jr)，美国德州大学(C Bucana) |
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| 摘 要： | 紫外线B照射可以改变小鼠皮肤的接触性过敏反应,并可以引起脾脏中抗原特异性T抑制细胞的出现。大量证据提示:表皮郎格罕氏细胞是紫外线照射引起上述反应的主要靶细胞之一,并导至抑制细胞的形成。本工作用各种细胞表面标记物和光镜、电镜技术确定正常与紫外线照射小鼠在接触性过敏反应中抗原呈递细胞所发生的变化。
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| 关 键 词： | 紫外线照射 接触性过敏 抗原呈递细胞 |
CHARACTERISTICS OF ANTIGEN-PRESENTING CELLS INVOLVED IN CONTACT SENSITIZATION OF NORMAL AND UV-IRRADIATED MICE |
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| Tang Junmin,et al. CHARACTERISTICS OF ANTIGEN-PRESENTING CELLS INVOLVED IN CONTACT SENSITIZATION OF NORMAL AND UV-IRRADIATED MICE[J]. Journal of Peking University. Health sciences, 1993, 0(5) |
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| Authors: | Tang Junmin et al |
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| Affiliation: | Tang Junmin,et al Department of Histology and Embryology |
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| Abstract: | Exposure of mice to UV-B (280-320 nm) radiation alters their immune response sensitizing haptensapplied to UV-irradiated skin. Under these conditions, the contact hypersensitivity response is reduced,and hapten-specific suppressor T-lymphocytes can be found in the spleen. Considerable evidencesuggests that the Langerhan'S cells are a kind of the target cells that have produced the effect of UVirradiation and lead, ultimately, to suppressor cell formation. A combination of cell surface markers andlight and electron microscopy have been used to determine whether difference can be detected in theantigen-presenting cells involved in contact sensitization of normal and UV-irradiated mice. |
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| Keywords: | UV-irradiation Contact hyper sensitization Antigen presenting cell |
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