45例慢性淋巴组织增生性疾病临床资料分析

目的:研究慢性淋巴组织增生性疾病的诊断和鉴别诊断方法。方法:对45例慢性淋巴组织增生性疾病(CLPD)的临床资料,包括临床征象、细胞形态学、免疫学标记等进行分析。结果:45例CLPD患者中慢性淋巴细胞白血病35例,幼淋细胞白血病8例,带有绒毛样淋巴细胞原发性淋巴瘤及毛细胞白血病各1例。35例CLL均为B细胞,其中CD5和CD19均阳性,而CD10均阴性,临床首发表现以血淋巴细胞增高为多见。8例PLL,6例为B细胞型,骨髓中以幼淋细胞为主,免疫表现CD5均阴性,CD19均阳性。结论:依据临床征象、细胞形态学和免疫表型分析,可诊断CLPD的各个类型。

Clinical analysis of 45 cases with chronic lymphoproliferative diseases

Objective:To explore the diagnosis and differentiate diagnosis of chronic lymphoproliferative diseases.Method:Clinical data of 45 cases with chronic lymphoproliferative diseases was analyzed, including clinical features, marrow cell morphology, immunophenotype, etc.Result:45patients consisted of 35 with CLL, 8 with PLL, 1 with HCL, 1 with ATLL. All 35 CLL cases had B-cell marker: CD19 . CD5 , CD10- , initial sign in most patients was lymphocytosis in routine blood test. 6 PLL expressed B-cell immunological marks: CD19 , CD5-. Pre-lymphocyted amounts increase in marrow. 2 PLL had T-cell marks.Conclusion:Diagnosis and differentiate diagnosis of CLPD should be synthetical analysis according to clinical features, cell morphology, immunological marker, molecular biology and genetics.