青年人与老年人胃癌的临床对比分析

目的探讨青年人胃癌区别于老年性胃癌的临床特点,并提出相应的治疗对策。方法对79例45岁以下(青年组)和120例65岁以上(老年组)胃癌患者的临床资料进行对比分析。结果两组患者性别构成差异无统计学意义(P=0.226)。与老年组比较,青年组患者早期无特异症状、病程较短(165dvs400d,P=0.029)、并以胃下部癌多见(49.4%vs41.7%,P=0.038);病理分期两组构成比比较,差异有统计学意义(P=0.027);总的中位生存时间,青年、老年组分别为1006d和530d(P=0.108);根治术后,青年、老年组的中位生存时间分别为1197d和919d,差异无统计学意义(P=0.242)。结论青年人胃癌具有症状无特异性、恶性度高、发展迅速等特性,但通过恰当的治疗,效果与老年患者无异。

Comparative study on clinical characteristics of gastric carcinoma between young and elderly patients

OBJECTIVE: To compare the clinical characteristics of gastric cancer between young and elderly patients,and bring forward corresponding countermeasures. METHODS: Clinical characteristics, treatment and prognosis between 79 young (or= 65 years old) patients were compared. RESULTS: The constituent ratio of gender between young and elderly group was not significantly different (P=0.226). There was no particularity of early symptom in young patients, but they had shorter course of disease (165 d vs 400 d, P=0.029) and more frequent inferior part of cancer (49.4% vs 41.7%, P=0.038) as compared to elderly patients. There was significant difference between two groups in pathological stage ratio (P=0.027). The median total survival time of young and elderly patients was 1006 d and 530 d respectively, which was not significantly different (P=0.108). Furthermore, median survival time of young and elderly patients after radical resection were 1197 d and 919 d respectively, and the difference was not significant as well (P=0.242). CONCLUSIONS: Characteristics of young patients with gastric cancer are lower incidence, larvaceous symptoms, more malignancy and quick development, which still remain general features of gastric cancer. By correct therapy, the efficacy of above young patients is similar to elderly patients. The key to improve prognosis is to further fortify cognition for gastric cancer and elevate early diagnostic rate.