PARticipation in inflammation |
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Authors: | Coughlin Shaun R Camerer Eric |
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Affiliation: | Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143, USA. coughlin@cvrimail.ucsf.edu |
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Abstract: | Graft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following conventional allogeneic hematopoietic stem cell transplantation (HSCT). A study in mice (see related article on pages 101–108) demonstrates that the selective administration of donor memory CD4+ T cells results in immune reconstitution without GVHD, a result that, if translatable to humans, has important clinical implications for HSCT. |
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