银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤的临床研究

目的 观察银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤的临床疗效。方法86例中晚期上消化道恶性肿瘤患者口服银杏外种皮多糖胶囊制剂，观察比较用药前后患者的临床症状和生存质量的改善情况。其中对于单用该制剂治疗的32例胃癌患者，用电子胃镜观察用药前后肿瘤大小的变化，计算肿瘤的客观缓解率，并进行生存期的随访。对于结合放疗的患者观察其血象的变化。结果 该制剂能明显改善患者的临床症状，显著提高患者的卡氏评分。在单用该制剂治疗的32例胃癌患者中，完全缓解2例(6．3％)、部分缓解22例(68．8％)、稳定5例(15．6％)，且生存期显著延长。该制剂还能改善放疗引起的患者造血功能的抑制和体重的下降。结论 银杏外种皮多糖胶囊制剂治疗中晚期上消化道恶性肿瘤具有一定的疗效。

Clinical study on treatment of patients with upper digestive tract malignant tumors of middle and late stage with Ginkgo biloba exocarp polysaccharides capsule preparation

OBJECTIVE: To observe the clinical efficacy of Ginkgo biloba exocarp polysaccharides (GBEP) capsule preparation in treating upper digestive tract malignant tumors of middle and late stage. METHODS: Eighty-six patients of the upper digestive tract malignant tumors were treated with GBEP capsule preparation taken orally. The clinical symptoms and the qualities of life of the patients with single GBEP and combined with operation, radiotherapy or intervention chemotherapy were observed. The tumor size was measured by electronic gastroscope before and after treatment with single GBEP. Objective response rate (RR) of the tumor was calculated. The survival period of patient was observed. The changes of blood routine examination in the patients treated with radiotherapy were observed. RESULTS: GBEP preparation could markedly improve the patients'clinical symptoms. Karnofsky scoring of the patients markedly increased after treatment. There were 2 CR (complete response, 6.3%), 22 PR (partial response, 68.8%)and 5 SD (stable disease, 15.6%) of 32 cases with single GBEP preparation. The survival periods of the 32 cases were markedly prolonged. The preparation could relieve the inhibited hematopietic function and the weight loss due to radiotherapy. CONCLUSION: GBEP capsule preparation has some definite therapeutic effects on upper digestive tract malignant tumors of middle and late stage.