Fusion of dynamic contrast-enhanced magnetic resonance mammography at 3.0T with X-ray mammograms: pilot study evaluation using dedicated semi-automatic registration software |
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Authors: | Dietzel Matthias Hopp Torsten Ruiter Nicole Zoubi Ramy Runnebaum Ingo B Kaiser Werner A Baltzer Pascal A T |
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Affiliation: | a Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07740 Jena, Germany b Karlsruhe Institute of Technology (KIT), Institute for Data Processing and Electronics, Postfach 3640, D-76021 Karlsruhe, Germany c Medical School; University of Harvard, 25 Shattuck Street, Boston, MA 02115, USA d Clinic of Gynecology and Obstetrics, Friedrich-Schiller-University Jena, Bachstraße 18, D-07743 Jena, Germany |
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Abstract: | Rationale and objectivesTo evaluate the semi-automatic image registration accuracy of X-ray-mammography (XR-M) with high-resolution high-field (3.0 T) MR-mammography (MR-M) in an initial pilot study.Material and methodsMR-M was acquired on a high-field clinical scanner at 3.0 T (T1-weighted 3D VIBE ± Gd). XR-M was obtained with state-of-the-art full-field digital systems. Seven patients with clearly delineable mass lesions >10 mm both in XR-M and MR-M were enrolled (exclusion criteria: previous breast surgery; surgical intervention between XR-M and MR-M).XR-M and MR-M were matched using a dedicated image-registration algorithm allowing semi-automatic non-linear deformation of MR-M based on finite-element modeling. To identify registration errors (RE) a virtual craniocaudal 2D mammogram was calculated by the software from MR-M (with and w/o Gadodiamide/Gd) and matched with corresponding XR-M. To quantify REs the geometric center of the lesions in the virtual vs. conventional mammogram were subtracted. The robustness of registration was quantified by registration of X-MRs to both MR-Ms with and w/o Gadodiamide.ResultsImage registration was performed successfully for all patients. Overall RE was 8.2 mm (1 min after Gd; confidence interval/CI: 2.0-14.4 mm, standard deviation/SD: 6.7 mm) vs. 8.9 mm (no Gd; CI: 4.0-13.9 mm, SD: 5.4 mm). The mean difference between pre- vs. post-contrast was 0.7 mm (SD: 1.9 mm).ConclusionImage registration of high-field 3.0 T MR-mammography with X-ray-mammography is feasible. For this study applying a high-resolution protocol at 3.0 T, the registration was robust and the overall registration error was sufficient for clinical application. |
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Keywords: | Mammography Magnetic resonance imaging Breast neoplasms Radiographic image interpretation Computer-assisted Image interpretation Computer-assisted Imaging Three-dimensional Humans Female Contrast media Gadolinium DTPA |
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