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First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies |
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| Authors: | Takashi Yamada Mamoru Morikawa Takahiro Yamada Reiko Kishi Kazuo Sengoku Toshiaki Endo Tsuyoshi Saito Kazutoshi Cho Hisanori Minakami |
| Affiliation: | 1. Department of Obstetrics, Hokkaido University Graduate School of Medicine, Kita-ku N14 W6, Sapporo, 060-8638, Japan 2. Center for Environmental and Health Sciences, Hokkaido University, Sapporo, Japan 3. Department of Obstetrics and Gynecology, Asahikawa Medical University Graduate School of Medicine, Asahikawa, Japan 4. Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan |
| Abstract: | ObjectivesTo determine whether a low serum folate level during the first trimester predicts subsequent late abortion, preterm birth, or fetal growth restriction (FGR).Study designA prospective cohort study involving 5,075 women whose serum folate levels were measured during the first trimester. The participants were informed of their serum folate levels.ResultsThe pregnancy duration, birthweight, rate of late abortion/preterm birth, and the rate of FGR did not differ significantly among the four groups classified according to folate status. The mean serum folate levels did not differ among quartiles classified according to the gestational week at the time of delivery. Nineteen of the 20 women with folate deficiency gave birth at term to infants with a birthweight of 3.132 ± 321 g; only one infant had FGR.ConclusionLow serum folate levels during the first trimester were not associated with the risk of late abortion, preterm birth, or FGR. |
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