茶对小鼠免疫功能的保护作用

目的探讨茶叶防癌的免疫调节机理。方法用致癌剂４甲基亚硝胺１（３吡啶）１丁酮（ＮＮＫ）诱发小鼠肿瘤的实验模型，观察ＮＮＫ所致小鼠免疫功能的改变及绿茶（ＧＴ）、复合茶（ＭＴ）和茶多酚（ＴＰ）的保护作用。结果小鼠注射ＮＮＫ后，在观察的４周内，腹腔巨噬细胞吞噬功能、外周血白细胞化学发光、迟发型变态反应、脾细胞抗体生成细胞数、以及脾ＮＫ活性等免疫指标，与正常对照组比较均出现不同程度的增高或降低；而ＧＴ、ＭＴ和ＴＰ对所有这些免疫功能的不良改变有明显的保护作用。结论茶及其成分对ＮＮＫ诱发小鼠肿瘤过程中早期所致免疫功能的改变具有保护作用

Protective Effect of Tea on Immune Function in Mice

Objective To study the mechanism of preventive effect of tea on cancer by immune regulation. Methods A tumor model was induced in mice using carcinogen, 4 methyl nitrosoamino 1 (3 pyridyl) 1 butanone (NNK), to examine their changes in immune function and the effects of green tea, mixed tea and polyphenol on protection from tumor. Results During the four weeks of observation after injection of NNK into mice, their immunological indicators, such as cytophagocytosis of macrophage in the abdominal cavity, chemiluminescence of peripheral leukocyte, delayed allergic reaction, count of antibody forming spleen cells and activity of spleen nature killer cells, etc. increased or decreased to various extent, as compared with those in normal controls. It was found that whether green tea, mixed tea or polyphenol all showed significant protection from adverse changes in immune functions. Conclusion Tea and its components had significant protection from early adverse changes in immune function in tumorgenesis induced by NNK.