| 托吡酯对氯氮平血药浓度的影响 |
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| 引用本文： | 周会爽,刘增龙,崔利军,苏丽惠,张云淑,郑冬瑞,毕皓,李娇. 托吡酯对氯氮平血药浓度的影响[J]. 中国健康心理学杂志, 2011, 19(9): 1027-1029 |
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| 作者姓名： | 周会爽 刘增龙 崔利军 苏丽惠 张云淑 郑冬瑞 毕皓 李娇 |
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| 作者单位： | 中国,河北省第六人民医院,保定,071000 |
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| 基金项目： | 保定市科学技术发展与规划项目(编号:08ZF0047) |
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| 摘 要： | 目的探讨托吡酯对氯氮平血药浓度的影响。方法采用前瞻性平行对照研究方法共纳入72例稳定服用氯氮平（治疗剂量或维持剂量）的患者,随机分为两组,一组合并托吡酯治疗（研究组）,另一组单用氯氮平治疗（对照组）。对研究组与对照组的临床资料进行比较。结果研究组与对照组氯氮平的血药浓度在基线、2月末、4月末和6月末比较,差异无统计学意义（t=0.719,0.857,1.196,0.378;P〉0.05）。结论托吡酯不影响氯氮平的血药浓度,两者可联合应用。
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| 关 键 词： | 抗精神病药物 氯氮平血药浓度 托吡酯 |
Effect of Topiramate on Plasma Concentrations of Clozapine |
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| Zhou Huishuang,Liu Zenglong,Cui Lijun,et al.. Effect of Topiramate on Plasma Concentrations of Clozapine[J]. china journal of health psychology, 2011, 19(9): 1027-1029 |
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| Authors: | Zhou Huishuang Liu Zenglong Cui Lijun et al. |
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| Affiliation: | Zhou Huishuang,Liu Zenglong,Cui Lijun,et al.The Sixth People's Hospital in Hebei Province,Baoding 071000,P.R.China |
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| Abstract: | Objective To explore the effect of Topiramate on plasma concentrations of Clozapine.Methods A prospective parallel controlled method were used to select 72 cases of patients who took stable therapeutic dose or maintenance dose of Clozapine.The patients were randomly divided into two groups: the group of combination of Topiramate treatment(study group),and group of Clozapine treatment alone(control group).The clinical data of study group and control group were comparedl.Results Compared the study group and c... |
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| Keywords: | Antipsychotic drugs Clozapine plasma concentration Topiramate |
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