丙戊酸镁缓释片与碳酸锂对躁狂发作的疗效及认知功能的对照研究

目的 比较丙戊酸镁缓释片与碳酸锂对躁狂发作患者的疗效及对认知功能的影响.方法 采用入院顺序分层随机法,将120例蹂狂发作患者平均分为研究组(丙戊酸镁缓释片)和对照组(碳酸锂),在治疗前,治疗后4、8、12周末各做1次韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击试验、动作功能测验、手功能协调测验、连线测验a和b...

Control Study on Efficacy and Cognition Function of Magnesium Valproate Retard Tablets and Lithium Carbonates in Manic Episode

】Objective To observe the efficacy and cognition function of Magnesium Valproate Retard Tablets and lithium carbonates in the treatment of manic episode.Methods A total of 120 manic episode patients were divided into study group（Magnesium Valproate Retard Tablets）and control group（lithium carbonates） randomly.Before treatment and at the end of 4,8,12 weeks,Wechsler adult intelligence scale,Wechsler memory scale,grooved pegboard test,finger tapping test,motor function test,hand coordination test,trail making test A and B,Wisconsin card sort test,and verbal fluency test were carried out,Effects and side effects were assessed with BRMS,CGI and TESS respectively.Results After 12-week treatment,there were significant differences in BRMS total scores between before and after treatment for both groups（t=2.87,P0.01）,and each factor score declined significantly（t=2.94,P0.01）,in study group,98.3% was efficient,71.7% was efficiency;in control group 96.7% efficient and 68.3% efficiency.There was no significant difference between them（t=0.38,P0.05）,side effect ratio in control group was higher than that in study group.Through 12-week treatment,there was gradual amendment of trend after 8 weeks,and significant differences in pound test,action ability test,hand function moderate test,WCST completion category number were found between them.Conclusion Magnesium valproate retard tablets is effective to treating manic episode,weaker side effects,and improving cognition function.