Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen

Authors:	Gaye?T?Adams,Harold?Snieder,Virgil?C?McKie,Betsy?Clair,Donald?Brambilla,Robert?J?Adams,Ferdane?Kutlar,Abdullah?Kutlar author-information" > author-information__contact u-icon-before" > mailto:akutlar@mcg.edu" title=" akutlar@mcg.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Sickle Cell Center, Department of Medicine, Medical College of Georgia, Augusta, GA;(2) Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA;(3) Twin Research and Genetic Epidemiology Unit, St. Thomas' Hospital, London, UK;(4) Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA;(5) Department of Neurology, Medical College of Georgia, Augusta, GA, USA;(6) New England Research Institute, Watertown, MA, USA

Abstract:	Background The phenotypic heterogeneity of sickle cell disease is likely the result of multiple genetic factors and their interaction with the sickle mutation. High transcranial doppler (TCD) velocities define a subgroup of children with sickle cell disease who are at increased risk for developing ischemic stroke. The genetic factors leading to the development of a high TCD velocity (i.e. cerebrovascular disease) and ultimately to stroke are not well characterized.

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