|
|||||
|
|
Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen |
|
| Authors: | Gaye?T?Adams Harold?Snieder Virgil?C?McKie Betsy?Clair Donald?Brambilla Robert?J?Adams Ferdane?Kutlar |
| Institution: | (1) Sickle Cell Center, Department of Medicine, Medical College of Georgia, Augusta, GA;(2) Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA;(3) Twin Research and Genetic Epidemiology Unit, St. Thomas' Hospital, London, UK;(4) Department of Pediatrics, Medical College of Georgia, Augusta, GA, USA;(5) Department of Neurology, Medical College of Georgia, Augusta, GA, USA;(6) New England Research Institute, Watertown, MA, USA |
| Abstract: | BackgroundThe phenotypic heterogeneity of sickle cell disease is likely the result of multiple genetic factors and their interaction with the sickle mutation. High transcranial doppler (TCD) velocities define a subgroup of children with sickle cell disease who are at increased risk for developing ischemic stroke. The genetic factors leading to the development of a high TCD velocity (i.e. cerebrovascular disease) and ultimately to stroke are not well characterized. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |