The resistance of cutaneous feline polymodal C-fiber units to tetrodotoxin as revealed by mechanical and thermal stimulation

Mechanical and thermal excitability of cutaneous feline polymodal C-fiber units is maintained under the action of subcutaneous tetrodotoxin injected in concentrations suppressing the mechanosensitivy of A_β-units. A number of features of inhibition and excitation of C-fiber polymodal sensory units can be explained by existence of tetrodotoxinresistant Na channels in their termination. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 369–371, October, 1997