Treatment of ABO Hemolytic Disease with Synthetic Blood Group Trisaccharides |
| |
| Authors: | Egidio L Romano res Soyano Ramón F Montaño Murray Ratcliffe Marilyn Olson Guillermo Suarez Nelly Martínez and Geoffrey Worstey |
| |
| Institution: | Laboratory of Pathophysiology, Instituto Venezolano de Investigaciones Científicas (I VIC), Caracas, Venezuela;Chembiomed Ltd, Edmonton, Alta., Canada;Maternidad 'Concepción Palacios', Caracas, Venezuela |
| |
| Abstract: | Thirteen infants, 10 with A-O and 3 with B-O hemolytic disease of the newborn (ABO-HDN), were treated with synthetic A or B blood group trisaccharides (ATS, BTS) which cause dissociation of maternal antibody bound to infant red cells. The clinical outcome was compared with that of a control group of 21 infants treated with phototherapy during the preceding year. Exchange transfusion was required in 2 out of 13 infants in the experimental group and in 7 in the control group. A randomized prospective controlled study is necessary to confirm these results. |
| |
| Keywords: | |
|
|
