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Influence of aging on thromboxane A2 and prostacyclin levels in rat hippocampal brain slices |
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| Authors: | Marmol F Puig-Parellada P Sanchez J Trullas R |
| Institution: | a Unitat de Farmacologia.IDIBAPS.(Institut d’Investigacions Biomèdiques August Pi I Sunyer) Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain b Unitat de Neurobiologia, IIBB, CSIC/IDIBAPS, Barcelona, Spain |
| Abstract: | We have investigated the influence of age (3, 18, 24 months) on Thromboxane A2 (TXA2) and Prostacyclin (PGI2) levels in hippocampal slices from F344/NHSD rats. A significant increase in TXA2 and PGI2 levels was observed in 18 and 24 months old compared to 3 months old animals. A significant reduction in the ratio TXA2/PGI2 produced by a higher increase in PGI2 was observed in 24 month old animals. The reduction in the TXA2/PGI2 ratio has been related to vasodilatory and antiaggregating effects that may contribute to protect the brain against neuronal damage. |
| Keywords: | Aging Thromboxane Prostacyclin Hippocampus |
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