| 诺氟沙星锌抗大鼠实验性胃溃疡作用研究 |
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| 引用本文： | 王胜浩,张信岳,郑高利,林芳,陈珏.诺氟沙星锌抗大鼠实验性胃溃疡作用研究[J].中国药房,2001,12(11):650-652. |
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| 作者姓名： | 王胜浩 张信岳 郑高利 林芳 陈珏 |
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| 作者单位： | 浙江省医学科学院药物研究所,杭州市,310013 |
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| 摘 要： | 目的 :研究诺氟沙星锌 (NF -Zn)的抗胃溃疡作用。方法 :采用大鼠的多种急、慢性胃溃疡模型 ,体外中和盐酸实验和抗幽门螺旋杆菌 (Hp)实验 ,评价药物的抗胃溃疡作用。结果 :NF -Zn能明显防止乙醇、水杨酸和应激所致的急性胃溃疡 ,明显促进醋酸浸渍所致慢性胃溃疡的愈合 ,降低胃酸的分泌 ,提高胃液的pH值。体外实验表明 ,NF -Zn具有明显的制酸作用 ,并能明显抑制Hp 的生长 ,其MIC50 为0 5μg/ml。结论 :NF -Zn具有制酸、保护胃粘膜和抑制Hp 的作用
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| 关 键 词： | 诺氟沙星锌 胃溃疡 幽门螺旋杆菌 |
| 文章编号： | 1001-0408(2001)11-0650-03 |
| 修稿时间： | 2001年4月3日 |
Study on the Action of Norfloxacin Zinc Against Experimental Gastric Ulcer in Rats |
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| WANG Shenghao,ZHANG Xinyue,ZHENG Gaoli,LIN Fang,CHEN Jue.Study on the Action of Norfloxacin Zinc Against Experimental Gastric Ulcer in Rats[J].China Pharmacy,2001,12(11):650-652. |
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| Authors: | WANG Shenghao ZHANG Xinyue ZHENG Gaoli LIN Fang CHEN Jue |
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| Abstract: | OBJECTIVE:To study the antiulcer action of norfloxacin zinc(NF-Zn) METHODS:Acute and chronic gastric ulcer models were established in rats and the in vitro action of neutralizing hydrochloric acid and the MIC for Hp of NF-Zn were determined RESULTS:NF-Zn could inhibit the formation of acute gastric ulcer induced by ethanol,stress and salicylic acid in rats,accelerate the healing of chronic gastric ulcer produced by acetic acid,inhibit the secretion of gastric acid and increase the pH in gastric juice In vitro,NF-Zn could neutralize HCl and inhibit Hp with MIC50 of 0 5μg/ml CONCLUSION:The results suggest that the antiulcer action of NF-Zn may be related with its protection of the gastric mucosal barrier,neutralization of acid and inhibition of Hp |
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| Keywords: | norfloxacin zinc gastric ulcer Hp |
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