急性冠状动脉综合征患者D-Ⅱ聚体、CD62p检测的临床意义

目的　探讨急性冠状动脉综合征 (ACS)患者血中D Ⅱ聚体、血小板膜糖蛋白CD6 2p阳性表达率测定的临床意义。方法　分别测定 2 1例稳定型心绞痛 (SA)患者、 2 2例不稳定型心绞痛 (UA)患者、14例急性心肌梗塞 (AMI)患者、 2 0例对照组患者的D Ⅱ聚体、CD6 2p、肌钙蛋白 (cTnI) ,分析不同组间各检出物的水平与ACS检出的敏感度。结果　指标的检测 :UA组和AMI组D Ⅱ聚体、CD6 2p的水平与SA组及对照组相比较差异有显著性 (P <0 0 1) ;UA组与AMI组相比 ,两者含量差异有显著性 (P <0 0 5 )。cTnI含量检测 :AMI组与其余 3组比较 ,差异有显著性 (P <0 0 1) ;而SA组与对照组比较 ,差异无显著性(P >0 0 5 )。D Ⅱ聚体、CD6 2p对ACS的检出均较cTnI为敏感。结论　D Ⅱ聚体、CD6 2p可作为冠状动脉内血栓形成的指标 ,并在一定程度上反映了UA的严重程度 ,它们在cTnI的基础上加强了临床对ACS的尽早确诊

Clinical significance of D-dimer and CD62p in patients with acute coronary syndrome

Objective To explore the clinical significance of D-dimer and CD62p in patients with acute coronary syndrome (ACS). Methods D-dimer,CD62p and cardiac troponin I(cTnl) in 77 patients were measured. These 77 patients included 21 with stable angina (SA),22 unstable angina (UA), 14 acute myocardial infarction (AMI),and 20 healthy subjects as control group. The levels of D-dimer,CD62p, and cTnI measured from each group were compared,and the sensitivity of diagnosing ACS was also compared.Results Compared with SA group and control group,there were significant differences in D-dimer and CD62p level in UA and AMI groups (all P<0.01).Furthermore, D-dimer and CD62p were significantly higher in AMI group than in UA group ( P<0.05 ). CTnl was significantly higher in AMI group than that in UA, SA and control groups (all P<0.01 ), while it did not differ significantly among UA, SA and control groups (P>0. O5).In the sensitivity test, D-dimer and CD62p were more sensitive than cTnl in diagnosing ACS.Conclusion D-dimer and CD62p can be regarded as the indexes of coronary thrombosis, and can reflect the severity of UA. Combined with cTnl measurement, they could help to diagnose ACS at an earlier phase.