高频振荡通气结合低浓度一氧化氮吸入对急性缺氧大鼠肺动脉高压的作用

目的：观察高频振荡通气（ＨＦＯ）联合低浓度一氧化氮（ＮＯ）吸入对急性缺氧大鼠肺动脉高压的治疗作用。方法：在ＨＦＯ下，经气管插管给大鼠１２％氧３０分钟制成急性缺氧肺动脉高压模型，行肺泡再充气，吸入低浓度ＮＯ（１０、５、２ｍｍｏｌ／Ｌ）对模型动物进行治疗，测定血流动力参数和血气值。结果：２～１０ｍｍｏｌ／Ｌ ＮＯ吸入均可逆转急性缺氧大鼠肺动脉压（ＰＡＰ），收缩压（ｓＰＡＰ）从４．４４～４．５３ｋＰａ（

Effects of high frequency oscillation combined with nitric oxide inhalation on pulmonary hypertension caused by acute hypoxia in rats

Objective:To investigate the therapeutic effects of inhaled nitric oxide(NO) combined with high frequency oscillation(HFO) on pulmonary hypertension caused by acute hypoxia in rats.Methods:An animal model of pulmonary hypertension produced by acute hypoxia in rat was established by inspiration of 12% O 2 through tracheostomy tube for 30 minutes in HFO mode.The animals were then treated with alveolar recruitment strategy followed by the inhalation of low concentration of NO (10,5,2 mmol/L).Haemodynamic monitoring and blood gas analyses were performed accordingly.Results:Compared with hypoxia only,the pulmonary arterial pressure (PAP) of rats in NO inhalation groups were significantly decreased.The levels of systolic PAP(sPAP),mean PAP(mPAP),diastolic PAP(dPAP) were decreased from 4 444 53 kPa(1 kPa= 7 5 mmHg ) to 3 383 48 kPa,from 2 582 87 kPa to 2 002 18 kPa,from 2 202 70 kPa to 1 67 1 82 kPa ,respectively.No obvious changes were observed in mean systemic arterial pressure(MSAP),heart rate,pH,PaO 2,intrapulmonary shunt ratio(s/t),and PaCO 2 (all P>0 05) between hypoxia only and treatment groups.Conclusions:HFO iNO (2 mmol/L) as a method of selective pulmonary vasodilation can be helpful for the treatment of pulmonary hypertension caused by acute hypoxia.The efficacy of NO on the pulmonary hypertension caused by the hypoxia is doseindependent (210 mmol/L).