Hyperimmunoglobulinemia D following cancer chemotherapy. |
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| Authors: | E Azuma S Masuda M Hanada Y W Zhou S L Zhang T Shibata Y Komada M Sakurai |
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| Affiliation: | Department of Pediatrics, Mie University School of Medicine, Japan. |
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| Abstract: | Five classes of serum immunoglobulin levels were investigated in 107 children with malignant or benign tumors. Hyperimmunoglobulinemia D (hyper-IgD) was observed in 31 of 82 children who were in complete remission off chemotherapy with a median follow-up of 4.5 years after cessation of chemotherapy. On the other hand, hyper-IgD was not found among 12 children with malignant or benign tumors treated with chemotherapy and a low incidence of hyper-IgD was observed during chemotherapy (1 of 13 cases). The result indicates that hyper-IgD is not uncommon in children off chemotherapy, suggesting that dysregulation of IgD synthesis persists long after cessation of antineoplastic drugs. |
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