Immunoglobulins of the tumor-bearing host as potential regulators of the tumor recurrence rate and metastasis development: a study on the model of ehrlich carcinoma

On the model of Ehrlich carcinoma transplanted in mice it is shown that following the removal of the primary tumor the organism of operated mice produces factors enhancing the rate of relapses and metastasis. The tumor cells are shown to fix on their surface immunoglobulins capable of enhancing tumor development in the mice. The serum-derived tumor-enhancing immunoglobulins undergo active pinocytosis by the tumor cells. The fall in the level of these immunoglobulins is accompanied by a reduction of the rate of tumor growth. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 62–64, January, 1995 Presented by Yu. N. Solov'ev, Member of the Russian Academy of Medical Sciences