银屑病早发型与晚发型临床差异的横断面调查

骆志成，Email: luozhc@lzu.edu.cn[摘要] 目的：调查早发型银屑病（发病年龄< 40岁）与晚发型银屑病（发病年龄≥40岁）之间的临床差异。方法：对患者实行调查问卷研究，内容包括性别、年龄、发病年龄、身高、体重、家族史、既往史、加重因素、甲损害、舌改变、瘙痒情况、合并症等。结果：共纳入了352名银屑病患者，其中早发型279例，晚发型73例。5.73%早发型和15.07%晚发型患者中出现掌跖损害，差异有统计学意义（χ2=7.170，P=0.007）。9.32%早发型和23.29%晚发型患者中出现合并症，差异有统计学意义（χ2=10.528，P=0.001）。73.13%早发型患者和44.83%晚发型患者在冬季复发加重，差异具有统计学意义(χ2=12.207，P＜0.01）。两组皮损PASI评分、SF-36量表总分、皮肤病生活质量评分（DLQI）方面，差异无统计学意义（P>0.05）。结论：早发型银屑病和晚发型银屑病存在临床差异。

Cross-sectional investigation on clinical characteristics of early-onset and late-onset psoriasis

Objective: To investigate the differences of clinical characteristics between early-onset psoriasis (age<40 years) and late-onset psoriasis (age≥40 years). Methods: All the patients with early and late-onset of psoriasis recruited in the study were asked to complete a questionnaires including gender, age, onset age, height, weight, family history, previous history, aggravating factors, nail damage, tongue changes, pruritus, complications. Results: The study included 352 psoriasis (279 early-onset and 73 late-onset). 5.73% early-onset patients and 15.07% late-onset patients had palmoplantar lesions, with a significant difference (χ2=7.170，P=0.007). 9.32% early-onset patients and 23.29% late-onset patients had complications, with a significant difference (χ2=10.528，P=0.001). 73.13% early-onset patients and 44.83% late-onset patients relapsed in the wintert with a significant difference (χ2=12.207,P＜0.01). There were no significant differences in PASI score, SF-36 score and DLQI score (Ps>0.05) between the two groups. Conclusion: There are different clinical characteristics between early-onset psoriasis and late-onset psoriasis.