子宫内膜异位症致不孕的机理探讨－血清中肿瘤坏死因子、白细胞介素Ⅱ、抗心磷脂抗体的检测

检测２４例子宫内膜异位症（ＥＭ）及１１例非子宫内膜异位症（ＮＥＭ）患者血清中的肿瘤坏死因子（ＴＮＦ）、白细胞介素Ⅱ（ＩＬ－２）及抗心磷脂抗体（ＡＣＡ）。结果：（１）３５例样本除ＥＭ组一例ＴＮＦ呈明显升高，其余均低于正常值（２μｇ／ｍｌ）；（２）ＥＭ组患者血清中ＩＬ－２的平均浓度为３１．１４６±２．２５１μｇ／ｍｌ，而ＮＥＭ组为８．２１７±３．８４４μｇ／ｍｌ，两者有显著性差异（Ｐ＜０．０１）；（３）ＥＭ组患者血清中ＡＣＡ阳性率为１６．６７％，ＮＥＭ组为２７．２７％。两者无显著性差异（Ｐ＞０．０５）。结论：ＥＭ患者血清胚胎毒性作用可能与ＩＬ－２有关，ＡＣＡ可能是非特异性的，而ＴＮＦ则无明显相关性。

The Examination of Tumor Necrosis Factor,Interleukin-2 and Anticardiolipin Antibody in Sera of Patients with Endometriosis

In order to testify whether the toxicity of sera from patients with endometriosis (EM) to early embryos is related to Tumor Necrosis Factor (TNF),Interleukin-2 (IL-2) and Anticardiolipin Antibody (ACA),the authors examined the sera of 24 patients with EM and 11 patients with non-endometriosis (NEM) diognosed by laparoscopy and laparotomy. The result: (1) TNF was negative in all but one sample of two groups. (2) The mean concentration of IL-2 in sera of EM group was 31. 146±2. 251μg/ml (x+s),while 8. 217±3. 844μg/ml of NEM group. There was significant defference between EM and NEM groups. (3) The positive ratio of ACA in sera of EM group and NEM group was 4/24 and 3/11 respectively. There was no significant differencebetween EM and NEM group. Conclusion:The toxicity of sera from patients with EM to early embryo is related to IL-2,but not to TNF and ACA.