Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment |
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Authors: | J. Harro Charlotta Löfberg Rein Pähkla Vallo Matto Lembit Rägo Lars Oreland Lembit Allikmets |
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Affiliation: | (1) Department of Pharmacology, University of Tartu, ülikooli 18, EE-2400 Tartu, Estonia, EE;(2) Department of Medical Pharmacology, University of Uppsala, Biomedical Centre, Box 593, S-75124 Uppsala, Sweden, SE |
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Abstract: | Cholecystokinin (CCK) is a neuropeptide recently implicated in affective disorders. This study aimed at measuring the levels of different molecular forms of CCK and the binding characteristics of CCKB receptors in the rat brain after three weeks of treatment with four different antidepressants, imipramine, amitriptyline, desipramine, and citalopram (all at the dose of 10 mg/kg once per day i.p.). Chronic treatment with imipramine and desipramine had a significant immobility-reducing effect in the Porsolt‘s swim test. The effect of amitriptyline, albeit in the same direction, was not significant, and citalopram had no effect in this test. In the elevated plus-maze test of anxiety, all drugs tended to increase the number of open arm entries and the ratio open/total arm entries, but only the effects of imipramine were statistically significant. None of the treatments affected the total levels of CCK or the levels of CCK-8-sulphated, CCK-8-nonsulphated, CCK-5, or CCK-4 in the frontal cortex. There was no effect of the treatments on CCKB receptor binding in the frontal cortex, hippocampus, or striatum. Imipramine and amitriptyline, however, increased the affinity of CCKB receptor binding in the hypothalamus. Thus, no consistent effect of chronic antidepressant treatment on the CCK-ergic neurotransmission in the rats was found. Received: 4 June 1996 / Accepted: 26 August 1996 |
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Keywords: | Cholecystokinin Antidepressants Chronic treatment CCK molecular forms CCKB receptors Porsolt‘ test Elevated plus-maze test |
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