移行带前列腺癌与良性前列腺增生患者磁共振波谱的检测

对2007年7月至2009年12月收治的20例移行带前列腺癌和20例良性前列腺增生（BPH）患者的磁共振波谱成像（MRSI）资料进行回顾性分析。移行带癌与增生活检组织体素的胆碱和肌酸与枸橼酸盐比值（CC／Ci）分别为2．26±1．35与0．81±0．22，胆碱与肌酸比值（Cho／Cr）分别为4．12±1．65与1．25±0．35，两者比较差异有统计学意义（t=5．17，t=7．16，均P〈0．01）；此二比值鉴别前列腺癌与BPH的特异性、敏感性和准确性分别为99％、86％和93％，有重要的临床价值。

Differentiation of prostate cancer from benign prostatic hyperplasia (BPH) in the transitional zone by magnetic resonance spectroscopic imaging

Twenty patients with prostate cancer and 20 patients with benign prostate hyperplasia (BPH) in the transitional zone underwent magnetic resonance imaging (MRI) /magnetic resonance spectroscopic imaging ( MRSI ) examinations. The choline + creatine/citrate (CC/Ci) ratio and the choline/creatine (Cho/Cr) ratio were evaluated in each voxel with cancer or BPH confirmed by pathological results.Discriminant analysis was used to determine the power of the two ratios in differentiation between cancer and BPH. The CC/Ci ratio and Cho/Cr ratio for cancer voxels were significantly higher than those in the voxels with BPH in the transitional zone (CC/Ci: 2.26 ± 1.35 vs. 0.81 ±0.22, t =5.17, P ＜0. 01, Cho/Cr:4. 12 ± 1.65 vs. 1.25 ±0. 35, P＜0. 01 ). As for the discriminant function with the CC/Cr ratio and the Cho/Cr ratio, the specificity, sensitivity, and accuracy were 99%, 86%, 93% respectively for the differentiation between cancer and BPH.