Effects of MK-801 on D1 dopamine receptor-mediated immediate early gene expression in the dopamine-depleted striatum |
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| Authors: | Ganguly A Keefe K A |
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| Institution: | Department of Pharmacology and Toxicology, University of Utah, 30 South, 2000 East #201, 84112-5820, Salt Lake City, UT, USA. |
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| Abstract: | Previous work indicates that intrastriatal administration of MK-801 does not completely block D1 agonist-induced gene expression in dopamine-depleted rats. The present study examined the effects of systemic MK-801 on such gene expression. A low dose of MK-801 did not affect induction of c-fos or zif268. A high dose completely blocked induction of c-fos, but only slightly suppressed zif268. The data suggest that NMDA receptor activity may not always be necessary for D1-induced gene expression. |
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| Keywords: | NMDA Basal ganglia zif268 c-fos Parkinson Glutamate |
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