| 膳食补充条斑紫菜对高血压患者血管内皮功能的影响 |
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| 引用本文： | 唐玉平,李鹏高,邢晓然,余振球,孙丽颖,肖忠新,张淑华,吴惠慧,褚金花,李卫新,甄亚平.膳食补充条斑紫菜对高血压患者血管内皮功能的影响[J].首都医学院学报,2008,29(4):475-478. |
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| 作者姓名： | 唐玉平 李鹏高 邢晓然 余振球 孙丽颖 肖忠新 张淑华 吴惠慧 褚金花 李卫新 甄亚平 |
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| 作者单位： | [1]首都医科大学燕京医学院预防医学系 [2]首都医科大学北京安贞医院高血压科 [3]首都医科大学临床检验中心 |
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| 摘 要： | 目的了解膳食补充条斑紫菜(Porphyra yezoensis)对原发性高血压(EH)患者血管内皮功能的影响。方法采取随机、空白对照、交叉设计的方法,将36名EH患者〔男,24人,平均年龄(55.0±7.9)岁;女,12人,平均年龄(50.5±7.1)岁〕分为2组,观察膳食补充条斑紫菜(45g/d)28d后血清内皮素(ET)及一氧化氮(NO)水平的变化情况。结果2组受试者补充条斑紫菜后ET水平分别降低了(16.3±8.6)ng/L和(22.2±8.8)ng/L,(P<0.05)。血清亚硝酸盐/硝酸盐(NO2-/NO3-)浓度分别升高了(15.8±5.8)μmol/L和(12.7±9.2)μmol/L,(P<0.05);且膳食补充组与空白对照组相比,ET和NO水平的变化均具有统计学意义(P<0.05)。结论条斑紫菜能改善EH患者血管内皮功能,舒张血管,降低血压。
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| 关 键 词： | 条斑紫菜 原发性高血压 内皮素 一氧化氮 |
| 收稿时间： | 2007-04-17 |
Influence of Dietary Supplementation of Purple Laver Porphyra yezoensis on Vascular Endothelial Function in Patients with Essential Hypertension |
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| Tang Yuping,Li Penggao,Xing Xiaoran,Yu Zhenqiu,Sun Liying,Xiao Zhongxin,Zhang Shuhua,Wu Huihui,Chu Jinhua,Li Weixin,Zhen Yaping.Influence of Dietary Supplementation of Purple Laver Porphyra yezoensis on Vascular Endothelial Function in Patients with Essential Hypertension[J].Journal of Capital University of Medical Sciences,2008,29(4):475-478. |
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| Authors: | Tang Yuping Li Penggao Xing Xiaoran Yu Zhenqiu Sun Liying Xiao Zhongxin Zhang Shuhua Wu Huihui Chu Jinhua Li Weixin Zhen Yaping |
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| Institution: | 1.Department of Public Health and Family Medicine;Yanjing Medical College;Capital Medical University;2.Department of Hypertension;Beijing Anzhen Hospital;3.Clinical Test Center;Capital Medical University |
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| Abstract: | We have previously reported that dietary supplementation with purple laver(PL) Porphyra yezoensis,an edible red alga,for 28 days reduced the 24 hour ambulatory blood pressure(ABP) in 36 patients with essential hypertension(EH).However,the antihypertensive mechanism of PL remain obscure and the influence of PL on vascular endothelial function,an important factor in the development and the treatment of EH is also unclear.Thus,to elucidate the mechanisms,we investigated the influence of dietary supplementation... |
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| Keywords: | Porphyra yezoensis essential hypertension endothelin nitric oxide |
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