中国汉族迟发型2型糖尿病与胰高血糖素受体基因Gly40Ser突变的关系

目的 :探讨胰高血糖素受体 (GCG R)基因外显子 2Gly40Ser突变是否与中国人迟发型非胰岛素依赖型糖尿病 (non -insulin -dependentdiabetesmillitus,NIDDM)相关。方法 :选择湖南地区汉族人NIDDM患者 82例及正常对照136例 ,应用聚合酶链反应———限制性片段长度多态分析方法 ,检测Gly40Ser突变。结果 :受检者均不存在Gly40Ser的错义突变。结论 :该突变不是引起中国人NIDDM的重要遗传因素。文献报道白种人GCG R基因Cly40Ser与NIDDM相关 ,本研究提示此种相关有种族差异性

Gly40Ser mutation of glucagon recepter gene and NIDDM in Han nationality

Objective To ascertain whether Gly40Ser mutation in exon 2 of glucagon recepter (GCG R) gene is associated with late onset non insulin dependent diabetes millitus (NIDDM) in Chinese. Methods We selected 82 NIDDM patients and 136 controls of Han nationality in Hunan province, and detected Gly40Ser mutation using polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). Results None of Gly40Ser mutation was found in all subjects. Conclusions The mutation doesn't associate with NIDDM in Chinese, even though the mutation was reported to be associated with NIDDM in certain French and Caucasians, genetic heterogeneity of NIDDM among ethnic groups should be considered.