| 2型糖尿病患者治疗前后内脂素与内皮素及胰岛素抵抗的关系 |
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| 引用本文： | 高谷,李倩,袁璐,丁波,李惠琴,马建华,齐绍康.2型糖尿病患者治疗前后内脂素与内皮素及胰岛素抵抗的关系[J].中华内分泌代谢杂志,2010,26(7). |
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| 作者姓名： | 高谷 李倩 袁璐 丁波 李惠琴 马建华 齐绍康 |
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| 作者单位： | 南京医科大学附属南京第一医院内分泌科,210006 |
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| 基金项目： | 南京市医学科技发展项目 |
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| 摘 要： | 探讨2型糖尿病发病机制中内脂素与内皮素及胰岛素抵抗的关系.比较治疗前后内皮素、内脂素等指标.治疗后内脂素水平降低,内皮素与空腹胰岛素、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、稳态模型评估的胰岛β细胞功能(HOMA-β)、内脂素正相关,内脂素与内皮素、HbA1c、空腹胰岛素、HOMA-IR正相关,HOMA-IR是血浆内脂素的独立相关因素.内脂素与内皮素、胰岛索抵抗有关,可能与2型糖尿病及胰岛素抵抗的发病机制密切相关.
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| 关 键 词： | 糖尿病 2型 内脂素 内皮素 胰岛素抵抗 甘精胰岛素 |
The relationship among plasma visfatin,endothelin, and insulin resistance in type 2 diabetic patients before and after treatment |
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| GAO Gu,LI Qian,YUAN Lu,DING Bo,LI Hui-qin,MA Jian-hua,QI Shao-kang.The relationship among plasma visfatin,endothelin, and insulin resistance in type 2 diabetic patients before and after treatment[J].Chinese Journal of Endocrinology and Metabolism,2010,26(7). |
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| Authors: | GAO Gu LI Qian YUAN Lu DING Bo LI Hui-qin MA Jian-hua QI Shao-kang |
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| Abstract: | The relationship between visfatin.endothelin, and insulin resistance in the pathogenesis of type 2 diabetes mellitus was explored. Endothelin, visfatin, and other markers were compared. Plasma visfatin was reduced after therapy. Endothelin was positively correlated with fasting insulin, HOMA-IR, HOMA-p, and visfatin. Visfatin was positively correlated with endothelin, HbA1C , fasting insulin, and HOMA-IR. HOMA-IR was an independent related factor in influencing visfatin. The visfatin is related to endothelin and insulin resistance, which may contribute to the pathogenesis of insulin resistance and type 2 diabetes mellitus. |
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| Keywords: | Diabetes mellitus type 2 Visfatin Endothelin Insulin resistance Insulin glargine |
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